It is a severe complication following open abdomen as a result of the exposure of abdominal viscera, with a mortality rate up to 35%. This study offers an effective method to produce curved structures and expands the potential applications of 4D printing in biomedical fields.Įnteroatmospheric fistula (EAF) is defined as an abnormal communication between the gastrointestinal tract and external atmosphere without overlaying soft tissue, , ]. The results illustrate that the hydrogel plays a role in the temporary closure of EAFs. Finally, we made a 4D-printed bilayer hydrogel stent to test its closure effect for enteroatmospheric fistulas (EAFs) in vitro and in vivo. The bilayer hydrogel can also curve in deionized water due to anisotropic volume change yet the response time and maximum bending degree was inferior to deformation in LA-Na and UV light. We explored various deformation steps in simple and complex constructs to verify that the 4D bilayer hydrogel can mimic the curved morphology of the intestines. The bending degree of this 4D construct can be programmed by modifying the pre-stretched lengths of the first layer. The deformation condition was to immerse the 4D construct in sodium lactate (LA-Na) and then expose it to ultraviolet (UV) light until maximal deformation was realized. The deformation process was actuated by the reduction of Fe 3+ to Fe 2+ in the first layer which restored it to its initial length. The first layer was first stretched and then formed reversible coordination with Fe 3+ to maintain this pre-stretched length it was later combined with a second layer. In this study, we presented a multi-responsive, flexible, and biocompatible 4D-printed bilayer hydrogel based on acrylamide-acrylic acid/cellulose nanocrystal (AAm-AAc/CNC) network. The 4D printing has the capacity to fabricate dynamic construction conforming to the natural bending of biological tissues, superior to other manufacturing techniques. Recently, four-dimensional (4D) shape-morphing structures, which can dynamically change shape over time, have attracted much attention in biomedical manufacturing.
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